Possible Interaction: Diclofenac and Glutamine

“Otherwise, the non-steroidal anti-inflammatory drugs nimesulide, acetylsalicylic acid, ibuprofen, and diclofenac sodium decreased the extracellular glutamate and glutamine levels, downregulated GS and AChE activities, and restored ACh levels in Pro-treated astrocytes.”

“Supplements with colostrum or glutamine reduced these changes induced by diclofenac , but this result was not seen for supplementation with low fat milk.”

“Administration of glutamine reduced the increase in intestinal permeability, protein losing enteropathy, enteric bacterial overgrowth and bacterial translocation induced by diclofenac.”