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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Diclofenac
supplement:
4-Hydroxybutyric Acid
Research Papers that Mention the Interaction
“In vitro studies with rat blood brain endothelial cells (RBE4) that express MCT1 indicated that diclofenac can inhibit GHB transport with an IC50 of 10.6 μM at pH 7.4.”
“With this study we can conclude that diclofenac and potentially other NSAIDs can inhibit the transport of GHB into the brain, therefore decreasing GHB's pharmacodynamic effects and toxicity.”
Drug‐drug interaction between diclofenac and gamma‐hydroxybutyric acid
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