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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
drug:
Dibucaine
supplement:
Epinephrine
Research Papers that Mention the Interaction
“ Hyperbaric dibucaine (cinchocaine) (Nupercaine) 5% in dextrose has a longer duration than that of hyperbaric bupivacaine (6), and its duration is reputed, although not documented, to be prolonged by the addition of 100-200 pg of epinephrine (7,8).”
Effect of epinephrine on the duration of dibucaine (cinchocaine) spinal anesthesia.“SummaryAn epidural block using dibucaine (Nupercaine) 1:1500 with epinephrine 1:200,000 will give analgesia during labour lasting up to six hours.”
“Coadministration of dibucaine with epinephrine produced a synergistic nociceptive block, whereas phentolamine blocked that synergistic block.”
“ Epinephrine synergistically enhances the effects of dibucaine , while phentolamine partially blocked those effects.”
“α-Adrenergic receptors play an important role in controlling synergistic analgesic effect of dibucaine combined with epinephrine.”
Phentolamine Reverses Epinephrine-Enhanced Skin Antinociception of Dibucaine in Rats.“ Dibucaine further elevated the concentration of cyclic AMP in the presence of adrenaline or adrenaline plus theophylline.”
“Coadministration of dibucaine with epinephrine produced a synergistic nociceptive block, whereas phentolamine blocked that synergistic block.”
“ Epinephrine synergistically enhances the effects of dibucaine , while phentolamine partially blocked those effects.”
“α-Adrenergic receptors play an important role in controlling synergistic analgesic effect of dibucaine combined with epinephrine.”
Phentolamine Reverses Epinephrine-Enhanced Skin Antinociception of Dibucaine in Rats.
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