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Last Updated: 4 months ago

Possible Interaction: Dibucaine and Epinephrine

supplement:

Epinephrine

Research Papers that Mention the Interaction

Hyperbaric dibucaine (cinchocaine) (Nupercaine) 5% in dextrose has a longer duration than that of hyperbaric bupivacaine (6), and its duration is reputed, although not documented, to be prolonged by the addition of 100-200 pg of epinephrine (7,8).
Anesthesia and analgesia  •  1989  |  View Paper
SummaryAn epidural block using dibucaine (Nupercaine) 1:1500 with epinephrine 1:200,000 will give analgesia during labour lasting up to six hours.
Canadian Anaesthetists' Society journal  •  1969  |  View Paper
Dibucaine further elevated the concentration of cyclic AMP in the presence of adrenaline or adrenaline plus theophylline.
The Biochemical journal  •  1974  |  View Paper
Coadministration of dibucaine with epinephrine produced a synergistic nociceptive block, whereas phentolamine blocked that synergistic block.
Epinephrine synergistically enhances the effects of dibucaine , while phentolamine partially blocked those effects.
α-Adrenergic receptors play an important role in controlling synergistic analgesic effect of dibucaine combined with epinephrine.
Anesthesia and analgesia  •  2019  |  View Paper
Coadministration of dibucaine with epinephrine produced a synergistic nociceptive block, whereas phentolamine blocked that synergistic block.
Epinephrine synergistically enhances the effects of dibucaine , while phentolamine partially blocked those effects.
α-Adrenergic receptors play an important role in controlling synergistic analgesic effect of dibucaine combined with epinephrine.
Anesthesia and analgesia  •  2018  |  View Paper