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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Dibucaine
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“Also, dibucaine increased intracellular calcium levels more effectively in calcium-containing Krebs-Ringer buffer than in calcium-free Krebs-Ringer buffer.”
Induction of apoptotic cell death in a neuroblastoma cell line by dibucaine.“LA's which are esters of p-aminobenzoic acid (including benzocaine), or which possess either an amide group dibucaine ), an amidine group (phenacaine), or an amino alkyl ether linkage (diphenhydramine) all produced a graded inhibition of the action of calcium , which was reversed by excess calcium (3 mM).”
The relation between the chemical structure of local anesthetics and inhibition of calcium-evoked secretion from the adrenal medulla“ Dibucaine also displaces Ca from the SL when applied to intact cells.”
“It is shown, in isolated SL, that dibucaine competitively displaces Ca specifically from anionic phospholipid headgroups.”
“Either verapamil or dibucaine attenuated the mitochondrial Ca uptake rate and reduced the rate of Ca-stimulated polyunsaturated free fatty acid accumulation; verapamil treatment also was associated with diminished net release of saturated and monounsaturated free fatty acids.”
“Although dibucaine inhibited the association induced by calcium alone, it did not affect the association induced by PMA alone.”
“ Dibucaine , however, inhibited the association which was induced synergistically by calcium and PMA.”
“Cosolvent-induced creatine kinase release was enhanced by the addition of calcium to the incubation medium, and inhibited, albeit modestly, by dibucaine , a nonspecific phospholipase A2 inhibitor.”
“ Abstract Dibucaine , tetracaine and lidocaine inhibited selectively Ca 2 + -calmodulin-induced activation of cyclic nucleotide phosphodiesterase with IC 50 values of 0.19, 0.44 and 4.80 mM, respectively and were less potent inhibitors in the absence of Ca 2+ .”
“Inhibition of NE dose-response curves by CE and low concentrations of D600 showed significant negative correlation with the concentration of calcium in the medium.”
“The inhibition of the F-component of NE- and KCl-induced responses by D600 and CE was inversely related to the concentration of calcium.”
“ATP-dependent Ca++ uptake was facilitated by 0.2 mM dibucaine only in the presence of a high concentration of Ca++.”
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