Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago

Possible Interaction: Diazoxide and Gamma-Aminobutyric Acid

drug:

Diazoxide

supplement:

Gamma-Aminobutyric Acid

Research Papers that Mention the Interaction

“ Diazoxide caused a twofold greater decrease in GABA levels, and glybenclamide increased VMH GABA levels by 57%.”
ATP-Sensitive K+ Channels Regulate the Release of GABA in the Ventromedial Hypothalamus During Hypoglycemia
Diabetes  •  2007  |  View Paper
“ Diazoxide , a sulfonylurea receptor 1 (SUR1)selective KATP-channel opener, prevented DA modulation by H2O2, glutamate, and GABA , whereas cromakalim, a SUR2-selective opener, did not.”
Activation of ATP-sensitive K+ (KATP) channels by H2O2 underlies glutamate-dependent inhibition of striatal dopamine release
Proceedings of the National Academy of Sciences of the United States of America  •  2003  |  View Paper
“ Diazoxide and cromakalim decreased the K(+)-evoked release of [3H]GABA from pallidal slices.”
Modulation of GABA Transmission by Diazoxide and Cromakalim in the Globus Pallidus: Implications for the Treatment of Parkinson's Disease
Experimental Neurology  •  1996  |  View Paper