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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Diazoxide
supplement:
Epinephrine
Research Papers that Mention the Interaction
“ Diazoxide resulted in a 37% increase in plasma levels of epinephrine and a 44% increase in plasma norepinephrine during hypoglycemia compared with placebo.”
Diazoxide Improves Hormonal Counterregulatory Responses to Acute Hypoglycemia in Long-standing Type 1 Diabetes“At a high concentration (250 microM), diazoxide repolarized the membrane to the resting potential and markedly accelerated 86Rb efflux both in the presence and absence of adrenaline.”
Non-additivity of adrenaline and galanin effects on 86Rb efflux and membrane potential in mouse B-cells suggests sharing of common targets.“Low concentrations (10-15 microM) of diazoxide , an activator of ATP-sensitive K+ channels, mimicked some effects of galanin and epinephrine.”
“And, based upon early reports by Tabachnick and coworkers,6 as well as their own findings, Graber and associates2 have concluded that diazoxide does not induce hyperglycemia directly, but first triggers epinephrine release, which in turn blocks insulin secretion and allows blood sugar to rise.”
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