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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Diazoxide
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“This characteristic distinguishes them from other drugs such as sodium nitroprusside, papaverine, hydralazine and diazoxide which interfere with the availability of calcium ions for their physiological functions by acting at sites other than the 'calcium channels'.”
Calcium antagonists. Pharmacodynamic effects and mechanism of action.“This characteristic distinguishes them from other drugs such as sodium nitroprusside, papaverine, hydralazine and diazoxide which interfere with the availability of calcium ions for their physiological functions by acting at sites other than the ‘calcium channels’.”
“Pretreatment with diazoxide resulted in a significant intracellular Ca and Mg loss in each experimental situation.”
“Infusion of diazoxide (600 mg) with calcium blocked the stimulation of the latter on insulin secretion.”
“It is suggested that diazoxide may act by displacing calcium at the receptor site, since its relaxant effect resembles the rapid response of magnesium and prevents the action of oxytocin.”
“A slight delay in Ca2+ -induced swelling of the mitochondria exposed to diazoxide could be result of an inhibition of succinate oxidation by the mitoKATP modulator.”
Closure of mitochondrial potassium channels favors opening of the Tl+-induced permeability transition pore in Ca2+-loaded rat liver mitochondria“This facilitation of the outward transport of calcium might explain why diazoxide inhibits the stimulant action of glucose upon calcium accumulation in the beta cell.”
“A … that DA activates ATP-dependent K + channels in the inner mitochondrial membrane [2], increases … the proton permeability of the inner mitochondrial membrane [2, 3], inhibits Ca 2 + influx and stimulates Ca 2+ efflux from the mitochondrial matrix [2, … the transmembrane potential ( ∆Ψ ) on the inner mitochondrial membrane [2].”
“Under these conditions, mitoKATP channel activity strongly regulated Δψm, and diazoxide prevented MPT by inhibiting the driving force for Ca uptake.”
“The effect of glucose on beta-cell spreading was mimicked by 25 mmol/l KCl (which induces calcium influx) and inhibited by diazoxide (which impairs depolarization and calcium entry ) and by the L-type Ca2+ channel blocker SR-7037.”
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