Possible Interaction: Diazepam and Yohimbine

“ DZ counteracted YOH effects on plasma cortisol on panic but not on other subjective measures or plasma prolactin.”

“ Diazepam caused a dose-related antagonism of yohimbine's stimulus properties.”

“ Yohimbine (1.0 mg/kg) also significantly shifted the dose-effect curve of diazepam cue to the right.”

“In line with the idea that cholecystokinin (CCK) is involved in anxiety-related behaviours, previous investigations showed that stressful conditions and an 'anxiogenic' drug, yohimbine , increased the cortical release of CCK like-material (CCKLM) in awake rats, and that this effect could be prevented by diazepam.”

“In addition, both quinine and yohimbine attenuated the effects of diazepam , an anxiolytic agent, in the open-field and thirst conflict tests.”

“The yohimbine cue was antagonized by clonidine (0.03-0.5 mg/kg) and diazepam (0.1-10.0 mg/kg).”

“The yohimbine cue was antagonized by both clonidine (0.03-0.5 mg/kg ip) and diazepam (0.1-10.0 mg/kg ip) in a dose-dependcnt manner.”

“There were no effects of neonatal treatment when the pups were tested undrugged in 3 animal tests of anxiety, but in the social interaction test the neonatal diazepam treatment significantly reduced the anxiogenic effects of yohimbine.”

“In agreement with the view that blockade of the stress-induced increases of NE turnover by benzodiazepines may be related to their antianxiety actions, it was found that the increase in NE turnover elicited by yohimbine , a drug that causes anxiety in man, is blocked by diazepam.”

“In agreement with the view that blockade of the stress-induced increases of NE turnover by benzodiazepines may be related to their antianxiety actions, it was found that the increase in NE turnover elicited by yohimbine , a drug that causes anxiety in man, is blocked by diazepam.”