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Last Updated: 2 years ago
drug:
Diazepam
supplement:
Tubocurarine
Research Papers that Mention the Interaction
“But a significant increase in both the degree and duration of block was observed when diazepam and d-tubocurarine were given simultaneously, suggesting an agonist action in diazepam.”
Effect of Diazepam on Neuromuscular Transmission and its Interaction with Non-Depolarizing Muscle Relaxants“Recently, Lorenzo Fernandez & Mediavilla Martinez (1973) reported that the commercially available solution of diazepam enhanced the recovery from the blockade caused by (+)-tubocurarine in the cat, but increased the recovery time of the succinylcholine blockade.”
“Vergano, Zaccagna & others (1969) showed that pretreatment with gallamine or (+)tubocurarine increased the transient blockade produced by diazepam in man as well as the frog sciatic nervegastrocnemius muscle preparation.”
Influence of diazepam on the effect of neuromuscular blocking agents“The commercial solvent for diazepam (Valium, Roche), in volumes that contained doses of 1–5 mg/kg of the drug, itself slightly enhanced the rate of recovery from block produced by tubocurarine or gallamine.”
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