Possible Interaction: Diazepam and Tryptophan

“1 Daily administration of diazepam or bromazepam (10 mg/kg) for 22 days significantly increased the activity of mid‐brain tryptophan hydroxylase by 36% and 39%, respectively.”

“An acute dose of diazepam (15 mg) significantly attenuated the prolactin and growth hormone responses to intravenous L-tryptophan.”

“ Acute diazepam diminished the prolactin neuroendocrine response to L-tryptophan.”

“Some drugs, e.g. antirheumatic drugs of the isopropionic acid-type, some antidiabetic agents, penicillin derivatives, benzodiazepines, tryptophan , dansylsarcosine, and suiphobromophthalein efficiently displace diazepam.”

“A decrease in the association constants of L-tryptophan and diazepam of about 30 - 50% and a decrease in the extrinsic Cotton effects of four benzodiazepine derivatives of about 10 - 15% were found as specific effects of the tryptophan modification.”

“Significantly increased tryptophan and serotonin concentrations were found in the intervention groups receiving higher doses of diazepam in 2.5 h exposure (p < 0.05 control versus intervention groups).”

“In the present report a series of tryptophan derivatives were tested for their ability to inhibit [3H] diazepam binding to rat brain synaptosomal membranes.”

“2 Acute administration of clonazepam and diazepam but not diphenylhydantoin raised cerebral tryptophan levels; chronic administration of clonazepam caused a smaller elevation of cerebral tryptophan but chronic administration of diazepam still caused a large rise in cerebral tryptophan.”

“Benzodiazepines diazepam , oxazepam, chlordiazepoxide) inhibited competitively the binding of tryptophan onto rat serum albumin.”