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“Diazepam DZP ) increased the levels of GABA and TAU and decreased the levels of GLU and GLY in this area.”
“In the hippocampus, only glutamate had its levels decreased after coumarin treatment, while diazepam increased the levels of GABA and TAU and decreased the levels of GLU in this brain region.”
“ Taurine at 10 mM had no effect on basal binding of [3H]diazepam to the membranes, while it significantly inhibited a GABA-stimulated binding of [3H]diazepam in cerebral cortex, hippocampus, but not in cerebellum.”
“1) and (3) as well as TAG (4), were found to antagonize the controlateral turning induced by the intracerebro injection of taurine and to potentiate the sedative effect of diazepam.”
“The incubation of whole blood with diazepam led to significant changes in PMN free glutamine, aspartate, glutamate, ornithine, arginine, citrulline, taurine and methionine as well as branched chain and neutral amino acid concentrations.”