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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Diazepam
supplement:
Serum Albumin, Human
Research Papers that Mention the Interaction
“Under conditions where Tyr411 is not acylated, the molar fraction of diazepam , diflunisal, ibuprofen, and 3-indoxyl-sulfate bound to HSA is higher than 0.9 whereas the molar fraction of propofol bound to HSA is ca.”
Ligand Binding to the FA3-FA4 Cleft Inhibits the Esterase-Like Activity of Human Serum Albumin“The addition of two or more moles of MYR, octanoate, and diazepam per mole of HSA caused a pronounced decrease in the labeling of the 11.6- and 13.5-kDa peptides.”
“Fluorescence polarization measurements and spectrofluorimetric results suggest that diazepam and Promen bind at different but interacting binding sites on the HSA.”
“ Diazepam was extensively bound by HSA and the percent free diazepam increased as drug concentration increased or as HSA concentration decreased.”
“One of them (R2-type drug, e.g., diazepam or medazepam) greatly accelerates the reaction of DA with HSA , and the other (R1-type drug, e.g., clofibric acid or octanoic acid) does not affect the reaction.”
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