Possible Interaction: Diazepam and Phosphatidylserine

“Before exposure to diazepam, chloride channels activated by … conductances of 8 to 53 pS. Diazepam caused a concentration-dependent and reversible increase in the conductance … these channels towards a maximum conductance of 70–80 pS and the effect was as great as …-fold in channels of lowest initial conductance.”

“Finally the antiepileptic effect of 0,2-0,5 mg/Kg diazepam , given in a single dose during the maximal epileptic activity resulted markedly reinforced in animals chronically treated with PS.”

“ Diazepam (1 and 2 mg/kg) used as a reference drug, markedly increased the choice preference for HRR ( PS 0.001: for both doses).”