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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Diazepam
supplement:
Oleic Acid
Research Papers that Mention the Interaction
“ Oleic acid decreases the binding of diazepam at all molar ratios of fatty acid:albumin.”
Intravascular factors affecting diazepam binding to human serum albumin.“Both qualitative and quantitative results suggest that oleic acid significantly affects the binding of diazepam , even at low molar ratios to albumin (below 1:1).”
“In neurosis diazepam (0.5 mg/kg, intraperitoneally, 40 minutes before the investigation) produced a decrease in the brain cortex of levels of arachidonic, oleic and myristic acids.”
[The effect of diazepam on the free fatty acid content in the brain structures of rats with an experimental neurosis].“ Oleic acid markedly improved the physical stability of a diazepam submicron emulsion.”
Characterization of diazepam submicron emulsion interface: role of oleic acid.
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