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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
Research Papers that Mention the Interaction
“ Inosine , 2-deoxyinosine, and 2-deoxyguanosine completely reversed the increase in exploratory activity elicited in mice by diazepam.”
Interaction between purine and benzodiazepine: Inosine reverses diazepam-induced stimulation of mouse exploratory behavior.“ Inosine , a putative benzodiazepine ligand, also enhanced diazepam action.”
Facilitation of diazepam action by anticonvulsant agents against picrotoxin induced convulsions“ Inosine , a purine that has recently been shown to be a competitive inhibitor of [3H] diazepam binding in vitro, antagonizes caffeine-induced seizures, while 7-methyl-inosine, a purine that lacks receptor binding inhibitory activity, has no effect on seizures.”
“Since the benzodiazepines, inosine , caffeine, and pentylenetetrazol all competitively inhibit [3H] diazepam binding and have marked effects on inducing or antagonizing seizures, further study of this receptor-ligand system may provide additional insights that concern possible biochemical mechanisms of seizures.”
“Adenosine (10(-6) M) and ATP (10(-6) M) were degraded to inactive inosine during incubation with atrial segments and their degradation was inhibited by diazepam.”
“ Inosine peripherally administered to rats markedly suppressed spontaneous food intake and food intake induced by diazepam , muscimol, insulin, and food deprivation.”
“ Inosine and nicotinamide completely prevented the GABA-mimetic action of diazepam but neither compound alone had any GABA-like activity.”
“Compounds such as inosine and hypoxanthine exhibit competitive inhibition of [3H] diazepam binding.”
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