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Last Updated: 2 years ago

Possible Interaction: Diazepam and Glycine

supplement:

Glycine

Research Papers that Mention the Interaction

Intra-periaqueductal injection of glycine markedly attenuated the anxiolytic effect of diazepam.
Behavioural Brain Research  •  1998  |  View Paper
However, 7-CLKYNA (100 nmol, ICV), but not strychnine (100 nmol, ICV), antagonized the anticonvulsant activity induced by coadministration of DZP (1.0 mg/kg, IP) and glycine (40 mmol/kg, PO).
This study evaluated a possible mechanism by which glycine potentiates the activity of diazepam (DZP) and valproic acid (VAL) against the clonic seizures induced by pentylenetetrazol (PTZ) in rats.
Pharmacology Biochemistry and Behavior  •  1994  |  View Paper
Coadministered with anticonvulsants, glycine significantly enhanced the anticonvulsant potency of diazepam and sodium valproate without affecting the neurological deficit induced by the anticonvulsants.
Brain Research Bulletin  •  1991  |  View Paper
Glycine also potentiated the anticonvulsant actions of MK-801 and diazepam but did not improve the selectivity of the drugs, as effective doses were still associated with neurotoxicity.
Neuropharmacology  •  1990  |  View Paper
Orally administered glycine (1.125 g/kg) potentiated the anticonvulsant effect of diazepam (DZP) to convert tonic-clonic electroshock seizures to less severe subthreshold clonic seizures.
Brain Research Bulletin  •  1987  |  View Paper
Administration of glycine (10 mmol/kg, oral) together with diazepam produced a significant reduction in both cortical epileptiform afterdischarge and the severity of seizures at doses of diazepam which had no significant effect on the seizures when administered alone.
Neuropharmacology  •  1986  |  View Paper