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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
drug:
Diazepam
supplement:
Adrenocorticotropic Hormone
Research Papers that Mention the Interaction
“ Diazepam caused dose-dependent decreases in cortisol and increases in GH and dose-independent decreases in ACTH.”
Neuroendocrine effects of diazepam in panic and generalized anxiety disorders“ Diazepam (1 mg/kg) completely blocked the effects of beta-CCE (200 micrograms/kg) on anxiety-related behaviors, heart rate and blood pressure, plasma catecholamines, cortisol, and adrenocorticotrophic hormone.”
“Phenytoin, ketoconazole, and cyproterone acetat modify the secretion of cortisol; opiates and diazepam inhibit that of ACTH.”
“Results Diazepam administered in a dose of 2.0 mg/kg suppressed basal HPA axis activity, ie, decreased plasma corticosterone and ACTH levels.”
The involvement of noradrenergic mechanisms in the suppressive effects of diazepam on the hypothalamic-pituitary-adrenal axis activity in female rats“ ACTH partly and corticosterone completely blocked the action of diazepam.”
“Both ether- and restraint-induced release of ACTH , but not B, were similarly and drastically reduced by diazepam and PC60 (1200 mg/kg).”
“ Chronic diazepam exposure reduced stress-induced corticosterone and ACTH release in OVX, but not male, rats.”
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