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Last Updated: 2 years ago

Possible Interaction: Diazepam and Adrenocorticotropic Hormone

Research Papers that Mention the Interaction

Diazepam caused dose-dependent decreases in cortisol and increases in GH and dose-independent decreases in ACTH.
Biological Psychiatry  •  1991  |  View Paper
Diazepam (1 mg/kg) completely blocked the effects of beta-CCE (200 micrograms/kg) on anxiety-related behaviors, heart rate and blood pressure, plasma catecholamines, cortisol, and adrenocorticotrophic hormone.
The Journal of neuroscience : the official journal of the Society for Neuroscience  •  1985  |  View Paper
Phenytoin, ketoconazole, and cyproterone acetat modify the secretion of cortisol; opiates and diazepam inhibit that of ACTH.
Fortschritte der Medizin  •  1995  |  View Paper
Results Diazepam administered in a dose of 2.0 mg/kg suppressed basal HPA axis activity, ie, decreased plasma corticosterone and ACTH levels.
Croatian medical journal  •  2012  |  View Paper
ACTH partly and corticosterone completely blocked the action of diazepam.
Bulletin of Experimental Biology and Medicine  •  2004  |  View Paper
Both ether- and restraint-induced release of ACTH , but not B, were similarly and drastically reduced by diazepam and PC60 (1200 mg/kg).
Psychopharmacology  •  2000  |  View Paper
Chronic diazepam exposure reduced stress-induced corticosterone and ACTH release in OVX, but not male, rats.
The Journal of pharmacology and experimental therapeutics  •  1996  |  View Paper