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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Dianhydrogalactitol
supplement:
Vitamin E
Research Papers that Mention the Interaction
“We have reported that d-alpha-tocopherol can prevent hyperglycemia-induced activation of DAG and PKC levels in vascular tissues as well as normalizing retinal blood flow and renal hyperfiltration.”
d-Alpha-tocopherol prevents the hyperglycemia induced activation of diacylglycerol (DAG)-protein kinase C (PKC) pathway in vascular smooth muscle cell by an increase of DAG kinase activity.“The presence of d-alpha-tocopherol (50 micrograms/ml) prevented the increase of both total DAG and [3H]-palmitate labeled DAG levels in cells exposed to 22 mM glucose.”
Prevention of diabetes-induced abnormal retinal blood flow by treatment with d-alpha-tocopherol.“ D-α-tocopherol prevented the glucose-stimulated increases in DAG level and PKC activity as well as the amount of PKC βII isoform in ASMCs cultured with elevated glucose levels.”
“Intraperitoneal injection of D-α-tocopherol (40 mg/kg) every other day resulted in a significant decrease of the elevated membranous PKC specific activity and total DAG levels in parallel with a significant increase of D-α-tocopherol content in the aorta.”
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