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“In vitro treatment with allitridin also increased significantly the percentages of Tc1, Tc2, and Th1, reduced the secreted levels of IL‐10 and TGF‐β1, and significantly suppressed viral loads.”
“ Allitridin could up-regulate the expression of T-bet and … and inhibit the expression of GATA-3 and IL-10 in MCMV-infected mice, indicating a Th1 dominant state, which should enhance the specific cellular … reactions against cytomegalovirus (CMV) and be helpful for clearance of CMV from the host.”
“ Allitridin induced significantly (P < .01) increased expression of the transcription factor T-bet and the Th1 cytokine IFN-gamma and markedly (P < .01) decreased expression of the transcription factor GATA-3 and the Th2 cytokine IL-10.”