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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Diallyl Trisulfide and Doxorubicin Hydrochloride

Research Papers that Mention the Interaction

Combination of DATS with Doxo -which exhibit different mechanisms of action- might be a potential novel strategy to augment Doxo-antitumor effect.
DATS and Doxo mono-treatments displayed opposing effect regarding expression of Notch signaling proteins and cyclin D1 gene expression.
However, DATS and Doxo co-treatment markedly decreased tumor volume and weight, increased animals' survival rate, and attenuated Doxo-induced tumor inflammation.
Pathology, research and practice  •  2020  |  View Paper
Immunohistochemical staining indicated that DATS decreased the expression of glial fibrillar acidic protein (GFAP) in DOX treated rats.
Our results showed that DATS treatment led to a decrease in plasma levels of tumor necrosis factor-alpha (TNF-α) induced by DOX.
Free radical biology & medicine  •  2020  |  View Paper
DATS increased the toxic effect of adriamycin on U2-OS cells.
Oncology reports  •  2014  |  View Paper
Compared with disulfide and thioether bonds, the trisulfide bond effectively promotes the self-assembly ability of doxorubicin homodimeric prodrugs, thereby improving the colloidal stability and in vivo fate of prodrug nanoassemblies.
Trisulfide bond enhances the stability and GSH sensitivity of doxorubicin dimeric prodrug nanoassemblies.
Science Advances  •  2020  |  View Paper
DATS could enhance the intracellular concentration of adriamycin by inhibiting the function and expression of P-gp, as shown by flow cytometry, RT-PCR, and western blot.
Evidence-based complementary and alternative medicine : eCAM  •  2012  |  View Paper