Possible Interaction: Dextromethorphan and Oligomeric Procyanidin Complex

“ DM had large effects on glial proliferation in less mature cultures in contrast to small variable effects in mature cultures; 1 μM DM stimulated proliferation of OPC by 4‐fold, microglia (MG) by 2.5‐fold and astroglia (AS) by 2‐fold.”

“In agreement with increased OPC proliferation, treatment of OPC with DM for 3 days increased the % of OPC relative to OL, with a smaller difference by 5 days, suggesting that maturation of OPC to OL was “catching up” by 5 days.”

“Thus, DM stimulates proliferation of OPC , and protects both OL and OPC against excitotoxic and inflammatory insults.”