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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Dextromethorphan
supplement:
Lysine
Research Papers that Mention the Interaction
“Reversal of the Glu-216 charge to Lys or substitution with neutral residues (Gln, Phe, or Leu) greatly decreased the affinity (K m values increased 10–100-fold) for the classical basic nitrogen-containing substrates bufuralol and dextromethorphan.”
Residues Glutamate 216 and Aspartate 301 Are Key Determinants of Substrate Specificity and Product Regioselectivity in Cytochrome P450 2D6*
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