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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Dextromethorphan
supplement:
Glutamine
Research Papers that Mention the Interaction
“ Q inhibits the rapid first-pass metabolism of DM.”
Treatment of pseudobulbar affect in ALS with dextromethorphan/quinidine“The inclusion of Q inhibits the rapid first-pass metabolism of DM to increase systemic concentrations of the drug in the plasma and, in theory, increase the potential efficacy.”
“Systemic concentrations of DM can be increased via coadministration of low-dose quinidine ( Q ), which reversibly inhibits its first-pass elimination.”
“DM is metabolized via cytochrome P450 2D6 (CYP2D6); Q is a CYP2D6 inhibitor used to increase DM plasma concentrations.”
“ DEX and LPS inhibited endothelial glutamine uptake in a time- and dose-dependent manner, a response that was only observed with incubation medium contained the lower concentrations of glutamine.”
“both DEX and LPS inhibited glutamine transport by decreasing transporter maximal transport velocity (Vmax) without affecting transporter affinity (Km).”
Inhibition of pulmonary microvascular endothelial glutamine transport by glucocorticoids and endotoxin.
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