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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Dextromethorphan and Glutamine

Research Papers that Mention the Interaction

Q inhibits the rapid first-pass metabolism of DM.
Neurology  •  2004  |  View Paper
The inclusion of Q inhibits the rapid first-pass metabolism of DM to increase systemic concentrations of the drug in the plasma and, in theory, increase the potential efficacy.
IDrugs : the investigational drugs journal  •  2010  |  View Paper
Systemic concentrations of DM can be increased via coadministration of low-dose quinidine ( Q ), which reversibly inhibits its first-pass elimination.
The neurologist  •  2007  |  View Paper
DM is metabolized via cytochrome P450 2D6 (CYP2D6); Q is a CYP2D6 inhibitor used to increase DM plasma concentrations.
Clinical Drug Investigation  •  2012  |  View Paper
DEX and LPS inhibited endothelial glutamine uptake in a time- and dose-dependent manner, a response that was only observed with incubation medium contained the lower concentrations of glutamine.
both DEX and LPS inhibited glutamine transport by decreasing transporter maximal transport velocity (Vmax) without affecting transporter affinity (Km).
JPEN. Journal of parenteral and enteral nutrition  •  1995  |  View Paper