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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Dextromethorphan
supplement:
Adrenocorticotropic Hormone
Research Papers that Mention the Interaction
“A reduced DEX suppression of baseline secretion of ACTH appeared 3 weeks after defeat.”
“ DEX pretreatment inhibited pituitary adrenocortical activity, reflected both in reduced baseline and response values of ACTH and CORT.”
“The ACTH response to CRF following DEX administration was significantly higher in defeated rats as compared to controls both at one and three weeks after defeat.”
Long‐Lasting Deficient Dexamethasone Suppression of Hypothalamic‐Pituitary‐Adrenocortical Activation Following Peripheral CRF Challenge in Socially Defeated Rats“With increasing DEX doses, ACTH and cortisol values decreased in young adult participants, while the decrease was blunted among elderly compared to young adult participants.”
“After the administration of math and speech stressors in a controlled laboratory setting, DEX inhibited the ACTH and cortisol release that was noted in the saline group, but stress-induced increases in EPI and NEPI were comparable in both groups.”
“ DEX produced a dramatic decrease in ACTH and cortisol levels, but no significant changes in EPI or NEPI occurred over a 4-h sampling interval.”
“ Basal ACTH and cortisol secretion remained suppressed throughout the night during both the Dex + ITT and Dex + hCRH + ITT studies when compared to the control study (cITT, P < 0.05).”
“ DEX showed significantly lowered ACTH concentrations from the day of drug injection (p<0.05).”
The effect of long-term exposure to combinations of growth promoters in Long Evans rats: part 1: Endocrine adrenal function.“Although both dextromethorphan and dextrorphan increased plasma levels of adrenocorticotropic hormone (ACTH) and corticosterone, the dextromethorphan-induced responses occurred more rapidly than the dextrorphan-induced responses.”
“This was evidenced in the latter animals by the fact that DEX was significantly less able to suppress the secretion of ACTH and corticosterone, and by a significantly higher release of ACTH after administration of CRF.”
“After DEX treatment, basal ACTH levels between 18.00 and 20.00 h were significantly higher in aged than in young rats (77.6 +/- 23.2 vs. 19.9 +/- 0.9 pg/ml; p < 0.01), indicating resistance of the HPA system to the suppressive effect of DEX.”
“ DEX (30 micrograms/kg) administered at 12.00 h, during the diurnal trough, suppressed the diurnal increase in circulating corticotropin (ACTH) and corticosterone between 18.00 and 20.00 h, during the acrophase.”
“We report an ICV DEX injection protocol (10 microgram given four times) that results in blocking the stress-induced release of ACTH and corticosterone, and attenuating the stress-induced release of plasma E and NE.”
“ DEX attenuated the vasopressin and ACTH responses to each infusion.”
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