Possible Interaction: Dextroamphetamine and Tyramine

“ Tyramine was a partial agonist and in its presence, β-PEA, d-amphetamine and octopamine were antagonised indicating that they all act through a common receptor for which tyramine serves as an antagonist.”

“In both tissues, d-amphetamine was shown to be a competitive inhibitor of the oxidation of TM.”

“3 (+)‐Amphetamine treatment (5 mg/kg) produced a reduction in p‐tyramine observed up to 4 h after its administration and no significant changes in m‐tyramine.”

“The stabilizable binding of phenylethylamine to calf midbrain (including corpus striatum) homogenates and synaptic membranes was decreased by dopamine; this amine and D-amphetamine also decreased the stabilizable binding of tyramine to rat brain homogenates.”

“Since tyramine treatment mimics the hyperthermic, but not the hypothermic, effects of D-amphetamine , and since D-amphetamine-induced hypothermia is blocked by pimozide, this hypothermia may involve central dopaminergic neurons.”

“The adrenaline beta-receptor blocking drug, pronethalol, and the sympathomimetic amines, (-)-ephedrine, (-)-amphetamine, dexamphetamine , (-)-Psi-ephedrine and tyramine, inhibited the sympathomimetic effects of butyrylcholine and tyramine on the guinea-pig isolated atrium.”

“Pheniprazine and dexamphetamine potentiated the responses to adrenaline, noradrenaline and tyramine , whereas nialamide only potentiated the response to tyramine.”