Possible Interaction: Dextroamphetamine and Sulpiride

“In the presence of (−)sulpiride (50 pmol/l), cyclic AMP formation was significantly increased at every concentration of d-amphetamine tested.”

“However, sulpiride at a dose of 75 mg/kg × 2, coadministered with D-amphetamine (7.5 mg/kg × 4), potentiated the increase in extracellular dopamine and initially slightly enhanced D-amphetamine-induced stereotypy.”

“SummaryThe decrease in … single injection of (+)-amphetamine sulfate (9.2 mg/kg) to iprindole-… haloperidol (0.2 mg/kg), sulpiride (32 mg/kg), pimozide (2 mg/kg), chlorpromazine hydrochloride (3.5 mg/kg), fluphenazine 2-…/kg) but not by (−)-butaclamol hydrochloride (1 mg/kg) or clozapine (40 mg/kg).”

“ Sulpiride , however, significantly attenuated d-amphetamine-induced locomotion and rearing compared to vehicle-treated controls.”

“The D-2 antagonists haloperidol and sulpiride decreased striatal neuronal activity in a dose-dependent manner and also effectively antagonized the effects of dexamphetamine.”

“Furthermore the stimulation of D1 receptors either by 2,3,4,5-tetrahydro,7,8-dihydroxy,1-phenyl,1-H,3-benzazepine or by D-amphetamine in the presence of S-sulpiride also enhanced the release of [3H]GABA.”

“Haloperidol, chlorpromazine and thioridazine blocked all ongoing behaviours while clozapine and sulpiride , regarded as causing less extrapyramidal side effects in the clinic, only antagonised the d-amphetamine induced locomotion.”

“Pimozide (4 mg/kg intraperitoneally) and L-sulpiride (40 mg/kg intraperitoneally) antagonized both the circling and increase in locomotor activity induced by quinine (0.1 mg/kg intra peritoneally) and D-amphetamine (4 mg/kg intraperitoneally) respectively.”