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Last Updated: 2 years ago

Possible Interaction: Dextroamphetamine and Serotonin

Research Papers that Mention the Interaction

The changes observed, particularly in DA and 5-HT metabolites, provide further evidence for an inhibitory role of brain 5-HT systems in the mediation of the behavioral effects of d-amphetamine and the catecholamine precursors, L-tyrosine and L-DOPA.
European journal of pharmacology  •  1984  |  View Paper
The combination of serotonin reuptake blockade and either presynaptic release of serotonin or monoamine oxidase inhibition by dexamphetamine will cause increased serotonin levels in the central nervous system, and is the likely mechanism of toxicity in this patient.
The Medical journal of Australia  •  2002  |  View Paper
Analogous results were observed for GBR12909 (1 and 3 mg/kg), whereas METH (0.3 and 1 mg/kg) increased DA and 5-HT.
Journal of Pharmacology and Experimental Therapeutics  •  2009  |  View Paper
ConclusionsWe conclude that cocaine and d-amphetamine increase DA and 5-HT levels in PRC and EC largely to the same extent as in the PFC.
or d-amphetamine (0, 0.5, 1.0, 2.5 mg/kg; i.p.).ResultsCocaine and d-amphetamine dose-dependently increased DA and 5-HT levels in the PRC, EC, and PFC.
Psychopharmacology  •  2007  |  View Paper
d-Amphetamine significantly increased the levels of 5-hydroxytryptamine , noradrenaline and dopamine in the hyperstriatum, brain stem and optic tectum of the chick respectively.
Psychopharmacology  •  2004  |  View Paper
The results suggest that low doses of d-amphetamine release 5-hydroxytryptamine , which in turn has an inhibitory effect on locomotor activity.
Psychopharmacology  •  2004  |  View Paper
Abstract Previously, we have demonstrated that 5-hydroxytryptamine (5-HT) injected into the nucleus accumbens attenuates the potentiating effects of d-amphetamine on responding for conditioned reward (CR).
Psychopharmacology  •  1999  |  View Paper
The 5-HT depleted rats showed increased responding for the lower doses of d-amphetamine , with a large significant increase in responding for the 7.5 µg/kg dose.
Psychopharmacology  •  1999  |  View Paper
inhibited D-amphetamine sulfate (1.0 mg/kg, s.c.)-induced increases in extracellular levels of both 5-HT and dopamine (DA) in rat medial prefrontal cortex, as determined by in vivo microdialysis.
Brain Research  •  1996  |  View Paper
At the doses used in this study, MDMA but not d-amphetamine increased the extracellular concentrations of 5-HT and decreased GABA efflux in the substantia nigra.
The Journal of pharmacology and experimental therapeutics  •  1995  |  View Paper
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