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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Dextroamphetamine
drug:
Serotonin
Research Papers that Mention the Interaction
“The changes observed, particularly in DA and 5-HT metabolites, provide further evidence for an inhibitory role of brain 5-HT systems in the mediation of the behavioral effects of d-amphetamine and the catecholamine precursors, L-tyrosine and L-DOPA.”
Effects of drug-induced changes in brain monoamines on aggression and motor behavior in mice.“The combination of serotonin reuptake blockade and either presynaptic release of serotonin or monoamine oxidase inhibition by dexamphetamine will cause increased serotonin levels in the central nervous system, and is the likely mechanism of toxicity in this patient.”
“Analogous results were observed for GBR12909 (1 and 3 mg/kg), whereas METH (0.3 and 1 mg/kg) increased DA and 5-HT.”
Evidence for the Involvement of Dopamine Transporters in Behavioral Stimulant Effects of Modafinil“ConclusionsWe conclude that cocaine and d-amphetamine increase DA and 5-HT levels in PRC and EC largely to the same extent as in the PFC.”
“or d-amphetamine (0, 0.5, 1.0, 2.5 mg/kg; i.p.).ResultsCocaine and d-amphetamine dose-dependently increased DA and 5-HT levels in the PRC, EC, and PFC.”
“ d-Amphetamine significantly increased the levels of 5-hydroxytryptamine , noradrenaline and dopamine in the hyperstriatum, brain stem and optic tectum of the chick respectively.”
“The results suggest that low doses of d-amphetamine release 5-hydroxytryptamine , which in turn has an inhibitory effect on locomotor activity.”
“Abstract Previously, we have demonstrated that 5-hydroxytryptamine (5-HT) injected into the nucleus accumbens attenuates the potentiating effects of d-amphetamine on responding for conditioned reward (CR).”
“The 5-HT depleted rats showed increased responding for the lower doses of d-amphetamine , with a large significant increase in responding for the 7.5 µg/kg dose.”
“inhibited D-amphetamine sulfate (1.0 mg/kg, s.c.)-induced increases in extracellular levels of both 5-HT and dopamine (DA) in rat medial prefrontal cortex, as determined by in vivo microdialysis.”
“At the doses used in this study, MDMA but not d-amphetamine increased the extracellular concentrations of 5-HT and decreased GABA efflux in the substantia nigra.”
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