Possible Interaction: Dextroamphetamine and Scopolamine

“Among the antimotion sickness drugs, only the combination of d-amphetamine (10 mg) plus scopolamine (0.6 mg) at altitude had a significant enhancing effect on performance relative to the reverse (depressing) effect found at sea level. (”

“ Scopolamine reversed the reduction in avoidance responding caused by spiperone and antagonized the inhibitory effects of spiperone on the behavioral actions of d-amphetamine or apomorphine.”

“Increases in motor activity, or sniffing plus licking and/or biting by d-amphetamine 1-DOPA, or SK and F 38393-A, in thirty and/or sixty day old rats are significantly enhanced by scopolamine pretreatment.”

“While scopolamine reduced alternation to chance levels, treatment with d-amphetamine produced marked perseverative behavior (i.e., below chance-level alternation).”

“For severe conditions of motion it is recommended that one of the following drug combinations be used: (1) scopolamine , 0.6 mg, plus dextroamphetamine sulfate , 5 mg, or (2) promethazine, 25 mg, plus ephedrine, 25 mg.”

“Twice the dose of hyoscine (1.2 mg) failed to increase its effectiveness; however, when it was used in combination with d-amphetamine the total number of tolerated head movements exceeded the sum of that with these drugs when they were tested alone.”

“The effects on this behavior of mixing d-amphetamine or methylphenidate with scopolamine or physostigmine suggest that this opposed action on rearing response duration is related to cholinergic-catecholaminergic balance.”

“Animals not allowed to self-stimulate but given d-amphetamine (2.0 mg/kg), scopolamine (2.0 mg/kg) showed a significant decrease in brain ACh.”

“Finally, scopolamine treatment augmented the perseverative effects of d-amphetamine.”

“The hyperactivity effects of d-amphetamine were approximately additive with scopolamine , whereas SKF 38393 did not significantly affect scopolamine.”