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Last Updated: 2 years ago

Possible Interaction: Dextroamphetamine and Scopolamine

Research Papers that Mention the Interaction

Among the antimotion sickness drugs, only the combination of d-amphetamine (10 mg) plus scopolamine (0.6 mg) at altitude had a significant enhancing effect on performance relative to the reverse (depressing) effect found at sea level. (
Aerospace medicine  •  1973  |  View Paper
Scopolamine reversed the reduction in avoidance responding caused by spiperone and antagonized the inhibitory effects of spiperone on the behavioral actions of d-amphetamine or apomorphine.
Psychopharmacology  •  2004  |  View Paper
Increases in motor activity, or sniffing plus licking and/or biting by d-amphetamine 1-DOPA, or SK and F 38393-A, in thirty and/or sixty day old rats are significantly enhanced by scopolamine pretreatment.
European journal of pharmacology  •  1981  |  View Paper
While scopolamine reduced alternation to chance levels, treatment with d-amphetamine produced marked perseverative behavior (i.e., below chance-level alternation).
Behavioral and neural biology  •  1979  |  View Paper
For severe conditions of motion it is recommended that one of the following drug combinations be used: (1) scopolamine , 0.6 mg, plus dextroamphetamine sulfate , 5 mg, or (2) promethazine, 25 mg, plus ephedrine, 25 mg.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery  •  1981  |  View Paper
Twice the dose of hyoscine (1.2 mg) failed to increase its effectiveness; however, when it was used in combination with d-amphetamine the total number of tolerated head movements exceeded the sum of that with these drugs when they were tested alone.
Aerospace medicine  •  1966  |  View Paper
The effects on this behavior of mixing d-amphetamine or methylphenidate with scopolamine or physostigmine suggest that this opposed action on rearing response duration is related to cholinergic-catecholaminergic balance.
Psychopharmacologia  •  2004  |  View Paper
Animals not allowed to self-stimulate but given d-amphetamine (2.0 mg/kg), scopolamine (2.0 mg/kg) showed a significant decrease in brain ACh.
Psychopharmacologia  •  2004  |  View Paper
Finally, scopolamine treatment augmented the perseverative effects of d-amphetamine.
Psychopharmacology  •  2004  |  View Paper
The hyperactivity effects of d-amphetamine were approximately additive with scopolamine , whereas SKF 38393 did not significantly affect scopolamine.
The Journal of pharmacology and experimental therapeutics  •  1990  |  View Paper
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