Possible Interaction: Dextroamphetamine and Risperidone

“ Risperidone pretreatment significantly attenuated the discriminative-stimulus effects of d-amphetamine , and some of the self-reported drug effects.”

“This report describes an acute dystonic reaction that occurred after dexamphetamine was discontinued from a drug regimen that included risperidone.”

“ d-Amphetamine was antagonized by haloperidol and risperidone (0.01 and 0.04 mg kg−1 s.c.).Conclusiond-Amphetamine-induced hyperlocomotion in miniature pigs may be a useful model for studying the effect of putative antipsychotics.”

“Pretreatment with haloperidol or risperidone abolished the effects of acute d-amphetamine on NT-LI and NPY-LI.”

“In the VSTR, haloperidol and risperidone (the higher dose) decreased NT-LI efflux and abolished the stimulatory effect of d-amphetamine (1.5 mg/kg, s.c.).”

“Classical antipsychotics (haloperidol, fluphenazine and cis(Z)-flupentixol) and the selective dopamine D2 receptor … remoxipride inhibit hypermotility in the two conditions with similar potencies, whereas sertindole, clozapine, risperidone , ziprasidone and olanzapine preferentially inhibit the effect of the low dose of D-amphetamine (selectivity ratios between 6.5 and 18).”

“Conclusions: In this case the use of lisdexamphetamine and risperidone may have set up an environment where there was decreased endogenously made dopamine and up-regulation of postsynaptic dopamine receptors.”