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Last Updated: 2 years ago

Possible Interaction: Dextroamphetamine and Raclopride

Research Papers that Mention the Interaction

LY379268 (10 mg/kg) and raclopride (3 mg/kg) blocked d-amphetamine and phencyclidine (PCP)-induced hyperactivity in wild-type mice.
Journal of Pharmacology and Experimental Therapeutics  •  2009  |  View Paper
The failure of D-amphetamine to produce an excitation is not due to an incomplete blockade of D2-like receptors by clozapine because co-treatment with clozapine and raclopride also failed to enable the excitatory effect of D-amphetamine.
Neuropsychopharmacology  •  2007  |  View Paper
Local injection of d-amphetamine sulphate (10 μg/0.5 μl) produced a marked increase in motor activity, measured as motility, locomotion, and rearing, which was dose- and time-dependently antagonised by local injection of raclopride (0.05–5.0 μg/0.5 μl).
Psychopharmacology  •  2004  |  View Paper
Raclopride (0.2 mg/kg) also partially but significantly reduced the locomotor stimulant effects of d-amphetamine in reserpinized mice.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2004  |  View Paper
Administered in a dose not influencing the spontaneous locomotor activity, SCH23390 and raclopride --selective antagonists of the D1 and D2 subtypes of dopamine receptors, respectively--abolished the hyperactivity induced by d-amphetamine , while not significantly changing the effect of sydnocarb.
Eksperimental'naia i klinicheskaia farmakologiia  •  2003  |  View Paper
Thus, using in vivo single-unit recording in rats, we found that the selective D2 antagonist raclopride not only blocked the inhibition induced by d-amphetamine but also enabled d-amphetamine to excite DA cells.
The Journal of Neuroscience  •  2000  |  View Paper
The selective D2 antagonist raclopride (0.1, 0.2, and 0.4 mg/kg) also reduced responding for d-amphetamine.
Pharmacology Biochemistry and Behavior  •  1998  |  View Paper
Low doses of d-amphetamine (0.5 mg/kg), sulpiride (4 mg/kg), pimozide (0.025 mg/kg), and raclopride (0.05 mg/kg) selectively enhanced responding on CR.
Pharmacology Biochemistry and Behavior  •  1997  |  View Paper
The selective D1 antagonist R(+/-)-SCH 23390 (0.1 mg/kg) and the selective D2 antagonist raclopride (1 mg/kg) had little effect on the stimulatory effect of dizocilpine, although they did reduce the stimulation produced by PCP, d-amphetamine and diazepam.
Behavioural Brain Research  •  1995  |  View Paper
The selective D1 receptor antagonist SCH23390 and selective D2 antagonist raclopride dose dependently inhibited the behavioral changes produced by 1.5 mg/kg d-amphetamine.
Therefore, this observation procedure revealed subtle differences between the inhibitory effects of SCH23390 and raclopride on d-amphetamine-induced behavioral changes.
Pharmacology Biochemistry and Behavior  •  1993  |  View Paper
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