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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Dextroamphetamine
drug:
Prazosin
Research Papers that Mention the Interaction
“Phenoxybenzamine, phentolamine and prazosin , which all block alpha-adrenergic receptors potentiated the inhibitory effect of D-amphetamine on lordosis behavior.”
Potentiation of D- and L-amphetamine effects on copulatory behavior in female rats by treatment with alpha-adrenoreceptor blocking drugs.“The d-amphetamine effect was slightly potentiated by prazosin , an α1-adrenoceptor antagonist, and mimicked by yohimbine, an α2 antagonist.”
cAMP and Extracellular Signal-Regulated Kinase Signaling in Response to d-Amphetamine and Methylphenidate in the Prefrontal Cortex in Vivo: Role of β1-Adrenoceptors“ResultsThe psychomotor stimulant effect of d-amphetamine , but not that of cocaine or apomorphine, was dose-dependently inhibited by clonidine and prazosin , and enhanced by propranolol.”
“The locomotor hyperactivity induced by systemic or local (nucleus accumbens) d-amphetamine injections can be blocked by systemic or local (prefrontal cortex) injections of prazosin , an α1-adrenergic antagonist (Blanc et al., 1994).”
“In the presence of a constant dose of prazosin , the dose-response curve for induction of rotation by AMPH was shifted to the right.”
“The selective alpha 1 antagonist, prazosin , dose-dependently attenuated the action of AMPH though rotation was not completely abolished.”
“Both clozapine and prazosin inhibited the d-amphetamine-induced locomotor stimulation in mice.”
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