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Last Updated: 2 years ago

Possible Interaction: Dextroamphetamine and Phentolamine

Research Papers that Mention the Interaction

Inspection of effects on individual doses of dexamphetamine showed that both phenoxybenzamine and phentolamine could potentiate the effectiveness of low doses of dexamphetamine.
Psychopharmacology  •  2004  |  View Paper
Phenoxybenzamine, phentolamine and prazosin, which all block alpha-adrenergic receptors potentiated the inhibitory effect of D-amphetamine on lordosis behavior.
Archives internationales de pharmacodynamie et de therapie  •  1979  |  View Paper
However, the fever induced by d-amphetamine was antagonized by pretreatment with yohimbine or phentolamine , but not with DL-propranolol in the rat.
Journal of Neural Transmission  •  2005  |  View Paper
The stimulation produced in dexamphetamine-(but not in vehicle-) treated mice by dexamphetamine was partially blocked by phentolamine , phenoxybenzamine, and propranolol.
Psychopharmacology  •  2004  |  View Paper
The difference in stimulation produced by dexamphetamine in the two groups was completely blocked by phenoxybenzamine (2.5 mg/kg), phentolamine (10 mg/kg), which drugs did not, however, block the locomotor stimulation produced by dexamphetamine in vehicle-treated animals.
Psychopharmacology  •  2004  |  View Paper
Further, local infusion of phentolamine (0.1 and 1 microM) and alprenolol (1 and 10 nM) appreciably and dose-dependently reduced the effects of AMPH on the DA increase in the mPFC.
The Journal of pharmacology and experimental therapeutics  •  1996  |  View Paper
The post-train depression in d-amphetamine was significantly reduced by the alpha-adrenoceptor antagonist, phentolamine (10(-5) M) and by the alpha 2-adrenoceptor antagonist, yohimbine (10(-6) M), but not by the alpha 1-adrenoceptor antagonist, prazosin (10(-5) M).
Archives internationales de pharmacodynamie et de therapie  •  1992  |  View Paper