Possible Interaction: Dextroamphetamine and Phentolamine

“Inspection of effects on individual doses of dexamphetamine showed that both phenoxybenzamine and phentolamine could potentiate the effectiveness of low doses of dexamphetamine.”

“Phenoxybenzamine, phentolamine and prazosin, which all block alpha-adrenergic receptors potentiated the inhibitory effect of D-amphetamine on lordosis behavior.”

“However, the fever induced by d-amphetamine was antagonized by pretreatment with yohimbine or phentolamine , but not with DL-propranolol in the rat.”

“The stimulation produced in dexamphetamine-(but not in vehicle-) treated mice by dexamphetamine was partially blocked by phentolamine , phenoxybenzamine, and propranolol.”

“The difference in stimulation produced by dexamphetamine in the two groups was completely blocked by phenoxybenzamine (2.5 mg/kg), phentolamine (10 mg/kg), which drugs did not, however, block the locomotor stimulation produced by dexamphetamine in vehicle-treated animals.”

“Further, local infusion of phentolamine (0.1 and 1 microM) and alprenolol (1 and 10 nM) appreciably and dose-dependently reduced the effects of AMPH on the DA increase in the mPFC.”

“The post-train depression in d-amphetamine was significantly reduced by the alpha-adrenoceptor antagonist, phentolamine (10(-5) M) and by the alpha 2-adrenoceptor antagonist, yohimbine (10(-6) M), but not by the alpha 1-adrenoceptor antagonist, prazosin (10(-5) M).”