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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Dextroamphetamine
drug:
Phencyclidine
Research Papers that Mention the Interaction
“A dose of phencyclidine (2.5 mg/kg) which had no effect when given alone, enhanced the behavioral effects of 1 and 3 mg/kg of d-amphetamine.”
The effects of phencyclidine on amphetamine stereotypy in rats.“ d-Amphetamine only slightly enhanced the rate-decreasing effects of phencyclidine.”
Interaction of the discriminative stimulus effects of phencyclidine with those of (+)-N-allynormetazocine, pentobarbital and d-amphetamine“In general, phencyclidine and d-amphetamine produced dose-dependent decreases in the overall response rates in both components.”
“Combinations of phencyclidine with a high dose of d-amphetamine generally produced supra-additive effects: i.e., the effects on rate and accuracy were greater than expected from simple addition of the effects of each drug given alone.”
“When phencyclidine was administered in combination with d-amphetamine , the phencyclidine dose-effect curves tended to shift to the left as the dose of d-amphetamine was increased.”
“That is, the effects of a given dose of phencyclidine and d-amphetamine together were less than an arithmetic summation of the effects of the drugs given alone.”
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