Possible Interaction: Dextroamphetamine and Pentobarbital

“These findings were thought to indicate that DA decreases “soundness” and “depth” of sleep while PB increases them.”

“Combinations of high d-amphetamine and pentobarbital doses yielded less than additive rate suppression.”

“Doses of 1.0 or 3.2 mg/kg d-amphetamine increased the dose of pentobarbital required for stimulus control in five of six birds.”

“The ability of d-amphetamine and ethanol to alter discriminative stimulus control by pentobarbital was examined in pigeons.”

“Higher doses of d-amphetamine generally enhanced the rate-decreasing effects produced by either ethanol or pentobarbital alone.”

“Increases in rates of responding produced by ethanol or pentobarbital under FI components were often enhanced following low to intermediate doses of d-amphetamine.”

“ d-Amphetamine in combination with pentobarbital or diazepam also increased the duration of rotarod impairment.”

“Analysis … that d-amphetamine tended to induce the animals to respond … maintaining the temporal pattern of responding, pentobarbital decreased the probability of responses late in the response-shock interval, and chlorpromazine and promazine increased … interval, producing a lessening of the temporal patterning of responding within the response-shock interval.”

“Combinations of d-amphetamine with either pentobarbital or chlordiazepoxide produced increases in punished responding that exceeded those obtained with either of these drugs alone.”

“Combinations of d-amphetamine with pentobarbital or chlordiazepoxide produced effects on both punished and unpunished responding that differed substantially from those obtained when any of these drugs were administered separately.”

“The combined effects of d-amphetamine and either pentobarbital or chlordiazepoxide on unpunished responding depended on the individual dose combinations.”

“In monkeys responding under the schedule of stimulus-shock termination, however, the effects of the two drugs were opposite: d-amphetamine markedly increased punished responding, whereas pentobarbital only decreased responding.”

“ Abstract Pentobarbital , chlordiazepoxide, diazepam, meprobamate and piperacetazine antagonized the anorectic effect of d-amphetamine.”

“Rules governing discrimination of the abused mixture of (+)-amphetamine plus pentobarbitone appeared generally similar to those found in previous studies with non-abused mixtures of nicotine and midazolam.”

“The reduced response to (+)-amphetamine after training in compound with the larger doses of pentobarbitone was attributed to overshadowing of a relatively weak (+)-amphetamine stimulus by a more salient pentobarbital stimulus.”