Possible Interaction: Dextroamphetamine and Pargyline

“The inhibition of 3H-acetylcholine release by (+)-amphetamine in rats pretreated with reserpine was potentiated in the presence of 10 μM pargyline.”

“ Chronic pargyline resulted in an enhanced sensitivity to the effects of d-amphetamine , ephedrine, tyramine, and morphine on schedule-controlled responding.”

“Daily pargyline resulted in an increased sensitivity to both the increases and decreases in response rates produced by d-amphetamine.”

“… d-amphetamine … pargyline increased the extracellular dopamine concentration, compared with pargyline-treated controls, to the same extent in both the substantia nigra (maximally by 360%) and … 400%), but the concomitant increase of 3-methoxytyramine accumulation in the dialysate was relatively smaller in the substantia nigra compared with the striatum.”

“Following pretreatment with pargyline (2 mg kg-1), d-amphetamine (5 mg kg-1) produced a significant reduction in striatal 2-phenylethylamine concentrations (to 39% of pargyline-treated controls).”

“The … AMPH to increase DA efflux and inhibit [3H]ACh release was blocked by inhibition of DA synthesis with alpha-methyl-p-tyrosine (100 microM) … by blockade of the DA neuronal uptake carrier with nomifensine (NOM) (10 microM) and was potentiated by inhibition of monoamine oxidase with pargyline (10 …).”

“Pretreatment with aMT or pargyline had little effect on the actions of the l-isomer, but reduced the magnitude and duration of the stimulatory effect of d-amphetamine.”