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Last Updated: 3 years ago

Possible Interaction: Dextroamphetamine and Nomifensine

Research Papers that Mention the Interaction

The neurons responded with large increases in extracellular striatal DA levels after the intrastriatal administration of the DA-releasing agent d-amphetamine and the DA-reuptake blocker nomifensine , although not to the same extent as seen in striata with an intact mesostriatal DA system.
Experimental Brain Research  •  2004  |  View Paper
Similar results could be obtained at lower concentrations of d-amphetamine (5 μmol/l), but only after inhibition of the dopamine neuronal reuptake system with nomifensine (30 gmol/1).
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2004  |  View Paper
By contrast, both clorgyline (0.1 pmol/l) and nomifensine (30 μmol/l) enhanced the d-amphetamine-induced increase in cyclic AMP formation.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2004  |  View Paper
Methylphenidate and d-amphetamine produced inconsistent results, and nomifensine produced a general reduction in responding.
Psychopharmacology  •  2004  |  View Paper
Correspondingly, the hydroxyl radical formation caused by AMPH in the striatum was attenuated by nomifensine , whereas its formation was not abolished by deprenyl.
The Chinese journal of physiology  •  2000  |  View Paper
NOM also blocked partially the ability of AMPH to reduce endogenous DOPAC efflux.
The … AMPH to increase DA efflux and inhibit [3H]ACh release was blocked by inhibition of DA synthesis with …-methyl-p-tyrosine (100 microM) or by blockade of the DA neuronal uptake carrier with nomifensine ( NOM ) (10 microM) and was potentiated by inhibition … monoamine oxidase with pargyline (10 microM).
The Journal of pharmacology and experimental therapeutics  •  1986  |  View Paper
ABSTRACT In accordance with the hypothesis that …-like central stimulants amfonelic acid, mazindol, nomifensine and methylphenidate produce their action by inhibiting the re-… of dopamine these compounds antagonized the stimulatory effect of (+)-amphetamine in reserpinized rats and mice at the same … as they caused central stimulation in normal animals.
Acta pharmacologica et toxicologica  •  1977  |  View Paper