Possible Interaction: Dextroamphetamine and Nomifensine

“The neurons responded with large increases in extracellular striatal DA levels after the intrastriatal administration of the DA-releasing agent d-amphetamine and the DA-reuptake blocker nomifensine , although not to the same extent as seen in striata with an intact mesostriatal DA system.”

“Similar results could be obtained at lower concentrations of d-amphetamine (5 μmol/l), but only after inhibition of the dopamine neuronal reuptake system with nomifensine (30 gmol/1).”

“By contrast, both clorgyline (0.1 pmol/l) and nomifensine (30 μmol/l) enhanced the d-amphetamine-induced increase in cyclic AMP formation.”

“Methylphenidate and d-amphetamine produced inconsistent results, and nomifensine produced a general reduction in responding.”

“Correspondingly, the hydroxyl radical formation caused by AMPH in the striatum was attenuated by nomifensine , whereas its formation was not abolished by deprenyl.”

“ NOM also blocked partially the ability of AMPH to reduce endogenous DOPAC efflux.”

“The … AMPH to increase DA efflux and inhibit [3H]ACh release was blocked by inhibition of DA synthesis with …-methyl-p-tyrosine (100 microM) or by blockade of the DA neuronal uptake carrier with nomifensine ( NOM ) (10 microM) and was potentiated by inhibition … monoamine oxidase with pargyline (10 microM).”

“ABSTRACT In accordance with the hypothesis that …-like central stimulants amfonelic acid, mazindol, nomifensine and methylphenidate produce their action by inhibiting the re-… of dopamine these compounds antagonized the stimulatory effect of (+)-amphetamine in reserpinized rats and mice at the same … as they caused central stimulation in normal animals.”