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Possible Interaction: Dextroamphetamine and Naloxone

Research Papers that Mention the Interaction

This effect was enhanced by subsequent systemic administration of D-amphetamine and blocked by previous treatment with naloxone.
European journal of pharmacology  •  1984  |  View Paper
Using perfused tissue slices, naloxone (10(-6)-10(-5) M) significantly attenuated the increase in [3H]DA release induced by d-amphetamine (10(-5) M) in both brain regions.
When the dose of d-amphetamine was increased to 3 mg/kg, naloxone (3 mg/kg) antagonized only the increase in rearing activity.
Neuropharmacology  •  1982  |  View Paper
NX can also significantly potentiate the central effects induced by DA agonists including DA agonist ( d-amphetamine ) induced 3H-dopamine release, and antagonize a number of the central effects elicited by DA release inhibiting agents.
The International journal of neuroscience  •  1982  |  View Paper
In contrast, response rates were reduced at all doses of d-amphetamine tested in the presence of naloxone.
Thus, the interaction between naloxone and d-amphetamine is qualitatively different from the one between naloxone and the analgesics.
Psychopharmacologia  •  2004  |  View Paper
The locomotor stimulating effect of d-amphetamine in mice was counteracted by the administration of l-naloxone [(-)-naloxone], a known opiate receptor antagonist.
Pharmacology Biochemistry and Behavior  •  1998  |  View Paper
While NX had no effect on its own in either of these preparations, it was able to significantly enhance the release of DA induced by d-amphetamine.
Neuropsychobiology  •  1984  |  View Paper
It is concluded that antagonism between NAL and AMPH could be due: (1) to enkephalinergic control of dopamine regulated nigral efferents, (2) to an action on the thalamic structures responsible for the reciprocal control of the two nigrostriatal dopaminergic pathways.
European journal of pharmacology  •  1983  |  View Paper
Naloxone was ineffective in blocking or reversing d-amphetamine inhibition of noradrenergic neuron activity.
European journal of pharmacology  •  1974  |  View Paper