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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Dextroamphetamine
drug:
Morphine
Research Papers that Mention the Interaction
“Experiments with animal and human subjects have provided evidence that both D-amphetamine and methylphenidate potentiate the analgesic effects of morphine.”
Effect of Modafinil on Acute Pain: A Randomized Double‐Blind Crossover Study“Combinations of morphine and d-amphetamine have been shown to be more effective in relieving pathological and experimental pain with fewer side effects than morphine alone.”
“Thus, the combination of morphine and d-amphetamine has a greater potential to be abused because of the additive euphoria and a lessening of side effects.”
“Analgesia, as measured by the patients' subjective responses … questions about relief of pain, was augmented when dextroamphetamine was … with morphine ; the combination of dextroamphetamine, 10 mg, with morphine was twice as potent as morphine alone, … the combination with 5 mg was 1 1/2 times as potent as morphine.”
“In simple performance tests, and in measures of side effects, dextroamphetamine generally offset undesirable effects of morphine (sedation and loss of alertness) while increasing analgesia.”
“Ingestion of these drugs did not affect the eventual development of dependence when solutions of morphine were substituted at a later stage, although the avoidance of dexamphetamine seemed to temporarily transfer to morphine.”
“The conclusion that morphine and d-amphetamine are 2 kinds of addictive drugs due to the reinforcement effects on ICSS" appears to be putting the incidental before the fundamental because these are addictive drugs in clinical use. (”
“Experiments with animal and human subjects provide convincing evidence that d-amphetamine or methylphenidate potentiate the analgesic effects of morphine.”
“ Morphine antagonized d-amphetamine circling in rats which had received unilateral 6-OHDA lesions of the striatum but failed to reduce the circling in rats with both a unilateral 6-OHDA striatal lesion and a raphe (5-HT) lesion.”
“Pretreatment with d-amphetamine (1 mg/kg intraperitoneally) significantly increased the intensity of the circling induced by morphine or FK 33-824, and pretreatment with haloperidol (0.5 mg/kg subcutaneously) attenuated this intensity.”
“While morphine (35 muM) did not affect the uptake of 14C-dopamine into the slices, d-amphetamine (50muM) and imipramine (100 muM) strongly inhibited it.”
“ d-Amphetamine increased while morphine decreased both responses.”
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