supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Dextroamphetamine
drug:
Modafinil
Research Papers that Mention the Interaction
“Although there was a slightly greater incidence of adverse events when modafinil and dextroamphetamine were administered together, the concomitant administration of the two drugs was well tolerated.”
Comparison of the Single‐Dose Pharmacokinetics and Tolerability of Modafinil and Dextroamphetamine Administered Alone or in Combination in Healthy Male Volunteers“ Modafinil pretreatment slightly increased the discrimination of low d-amphetamine doses in animals trained to discriminate 0.3 mg/kg d-amphetamine.”
“These results support previous findings that modafinil and d-amphetamine may have additive effects.”
Combined effects of modafinil and d-amphetamine in male Sprague–Dawley rats trained to discriminate d-amphetamine“Although the current results predict a low abuse liability with concurrent use of modafinil and d-amphetamine , additional research with higher dose combinations may be warranted before ruling out the possibility that these drugs could have additive or synergistic effects.”
“Participants receiving the combination of modafinil and d-amphetamine showed a trend of increased cocaine use over time with a corresponding low Bayesian probability of benefit (33%).”
“We hypothesized that the combination of modafinil and d-amphetamine , at low doses, would show equivalent or greater benefit in reducing cocaine use compared to higher doses of each individual medication or placebo.”
Combination of Modafinil and d-amphetamine for the Treatment of Cocaine Dependence: A Preliminary Investigation
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback