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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Dextroamphetamine and Modafinil

Research Papers that Mention the Interaction

Although there was a slightly greater incidence of adverse events when modafinil and dextroamphetamine were administered together, the concomitant administration of the two drugs was well tolerated.
Journal of clinical pharmacology  •  1998  |  View Paper
Modafinil pretreatment slightly increased the discrimination of low d-amphetamine doses in animals trained to discriminate 0.3 mg/kg d-amphetamine.
These results support previous findings that modafinil and d-amphetamine may have additive effects.
Pharmacology Biochemistry and Behavior  •  2013  |  View Paper
Although the current results predict a low abuse liability with concurrent use of modafinil and d-amphetamine , additional research with higher dose combinations may be warranted before ruling out the possibility that these drugs could have additive or synergistic effects.
Experimental and clinical psychopharmacology  •  2013  |  View Paper
Participants receiving the combination of modafinil and d-amphetamine showed a trend of increased cocaine use over time with a corresponding low Bayesian probability of benefit (33%).
We hypothesized that the combination of modafinil and d-amphetamine , at low doses, would show equivalent or greater benefit in reducing cocaine use compared to higher doses of each individual medication or placebo.
Front. Psychiatry  •  2012  |  View Paper