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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Dextroamphetamine
drug:
Methylphenidate
Research Papers that Mention the Interaction
“The results of this experiment are concordant with previous studies and suggest that the behavioral effects of oral methylphenidate and d-amphetamine overlap extensively and that the discriminative-stimulus effects of methylphenidate and d-amphetamine are symmetrical.”
Discriminative stimulus and self-reported effects of methylphenidate, d-amphetamine, and triazolam in methylphenidate-trained humans.“Both methylphenidate and d-amphetamine produced dose-dependent increases in stimulant-like subject ratings (e.g. Active, Alert, or Energetic and High), but the effects of these drugs were not isomorphic.”
“The intermediate dose of methylphenidate and d-amphetamine increased responding significantly above placebo levels.”
“These results further demonstrate that the acute behavioral effects of d-amphetamine and methylphenidate overlap extensively in humans, which is concordant with preclinical studies.”
“The occurrence of abnormal movements or perserverative/compulsive behaviors was noted in 34 (76%) of a group of 45 hyperactive boys during a double-blind crossover treatment trial of methylphenidate and dextroamphetamine given in a wide range of doses.”
“Whereas PCP potentiated the locomotor activity induced by d-amphetamine in both reserpine- and vehicle-pretreated subjects, methylphenidate marginally antagonized d-amphetamine-induced stereotypy in reserpine-pretreated subjects.”
“If methylphenidate acts by inhibiting the dopamine uptake it should antagonize the skeotypied behaviour produced by (+)-amphetamine m merpinized rats, in which methylphenidate itself has activity, but not influence the stereotypies by apomorphine which acts directly on the dopamine receptors (Emst, 1965).”
“She argues that: dexamphetamine prescription rates have markedly decreased since the availability of slow release methylphenidate capsules , which are much more difficult to divert.”
“Response to methylphenidate was associated with increases in inattention on a continuous performance task after dextroamphetamine challenge.”
“ Methylphenidate and dextroamphetamine caused marked aggravation of his motor and vocal tics.”
“These findings suggest that early exposure do methylphenidate might increase the risk for subsequent D-amphetamine abuse.”
Sensitization and cross-sensitization after chronic treatment with methylphenidate in adolescent Wistar rats
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