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Possible Interaction: Dextroamphetamine and Methylphenidate

Research Papers that Mention the Interaction

The results of this experiment are concordant with previous studies and suggest that the behavioral effects of oral methylphenidate and d-amphetamine overlap extensively and that the discriminative-stimulus effects of methylphenidate and d-amphetamine are symmetrical.
Experimental and clinical psychopharmacology  •  2005  |  View Paper
Both methylphenidate and d-amphetamine produced dose-dependent increases in stimulant-like subject ratings (e.g. Active, Alert, or Energetic and High), but the effects of these drugs were not isomorphic.
The intermediate dose of methylphenidate and d-amphetamine increased responding significantly above placebo levels.
Journal of psychopharmacology  •  2004  |  View Paper
These results further demonstrate that the acute behavioral effects of d-amphetamine and methylphenidate overlap extensively in humans, which is concordant with preclinical studies.
Experimental and clinical psychopharmacology  •  1998  |  View Paper
The occurrence of abnormal movements or perserverative/compulsive behaviors was noted in 34 (76%) of a group of 45 hyperactive boys during a double-blind crossover treatment trial of methylphenidate and dextroamphetamine given in a wide range of doses.
Psychiatry Research  •  1990  |  View Paper
Whereas PCP potentiated the locomotor activity induced by d-amphetamine in both reserpine- and vehicle-pretreated subjects, methylphenidate marginally antagonized d-amphetamine-induced stereotypy in reserpine-pretreated subjects.
Pharmacology Biochemistry and Behavior  •  1980  |  View Paper
If methylphenidate acts by inhibiting the dopamine uptake it should antagonize the skeotypied behaviour produced by (+)-amphetamine m merpinized rats, in which methylphenidate itself has activity, but not influence the stereotypies by apomorphine which acts directly on the dopamine receptors (Emst, 1965).
The Journal of pharmacy and pharmacology  •  1978  |  View Paper
She argues that: dexamphetamine prescription rates have markedly decreased since the availability of slow release methylphenidate capsules , which are much more difficult to divert.
The Australian and New Zealand journal of psychiatry  •  2013  |  View Paper
Response to methylphenidate was associated with increases in inattention on a continuous performance task after dextroamphetamine challenge.
Journal of clinical psychopharmacology  •  2008  |  View Paper
Methylphenidate and dextroamphetamine caused marked aggravation of his motor and vocal tics.
European Child & Adolescent Psychiatry  •  2002  |  View Paper
These findings suggest that early exposure do methylphenidate might increase the risk for subsequent D-amphetamine abuse.
Behavioural pharmacology  •  2007  |  View Paper
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