Possible Interaction: Dextroamphetamine and Methamphetamine

“The acute effects of intranasal methamphetamine were significantly diminished during d-amphetamine maintenance relative to placebo maintenance.”

“We predicted d-amphetamine maintenance would attenuate the acute subjective effects of intranasal methamphetamine.”

“Although d-amphetamine attenuated some subject-rated effects of methamphetamine , the self-administration results are concordant with those of clinical trials showing that d-amphetamine did not reduce methamphetamine use.”

“ Methamphetamine produced significant increases in systolic blood pressure, which were attenuated by d-amphetamine maintenance compared to placebo maintenance.”

“We predicted that d-amphetamine maintenance would reduce methamphetamine self-administration.”

“However, 0.1mg/kg/h d-amphetamine did eliminate methamphetamine choice in two monkeys.”

“Chronic administration of d-A and METH (3.2 mg/kg/12 hr for 7 days) resulted in cross-tolerance to the self-administration of cocaine under this progressive-ratio schedule.”

“It was found, too, that both dextroamphetamine and methamphetamine treated embryos frequently exhibited a significant decrease in crown rump length and cross-sectional area of the notochord, neural tube, dorsal aortae and whole body section, when compared with unopened or saline injected controls.”

“It could be demonstrated that (+)-amphetamine and N-methylamphetamine at a high concentration also antagonized the efflux evoked by low external Na+ concentrations and it is suggested that this effect is produced by inhibition of the outward transport of bretylium through the neurone membrane.”