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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Dextroamphetamine
Research Papers that Mention the Interaction
“Thus, the increase of striatal dopamine efflux and subsequent increase of locomotor activity following d-amphetamine is less prominent and slower to attain maximal effect following an equimolar dose of LDX.”
Preclinical pharmacokinetics, pharmacology and toxicology of lisdexamfetamine: A novel d-amphetamine pro-drug“LDX is hydrolysed in the blood …-amphetamine, and the pharmacokinetic profile of d-amphetamine following … LDX has a lower maximum plasma concentration (Cmax), extended time to Cmax (Tmax) and lower inter- and intra-… exposure compared with the pharmacokinetic profile of an equivalent dose of immediate-release (IR) d-amphetamine.”
“ LDX , a long-acting prodrug of d-amphetamine , has been reported to be effective and appears to overcome some of these limitations.”
“Toxicokinetic assessments indicated that as the dose of LDX was increased, rats were exposed to increasing levels of LDX and d-amphetamine.”
Toxicity profile of lisdexamfetamine dimesylate in three independent rat toxicology studies.
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