Possible Interaction: Dextroamphetamine and Imipramine

“Carbamazepine-induced mania is described in two case reports of prepubertal boys, one of whom also developed manic symptoms after receiving imipramine and dextroamphetamine.”

“It was further noticed that well developed d-amphetamine symptoms were interrupted by subsequent treatment with imipramine.”

“For example, chronic administration of tricyclic antidepressant drugs such as imipramine and desipramine (DMI) enhances the locomotor stimulant effects of d-amphetamine.”

“The psychomotor stimulants cocaine and d-amphetamine also occasioned responding on the imipramine key, as did the NE reuptake inhibitor tomoxetine; nomifensine, which blocks the reuptake of both NE and dopamine (DA), also resulted in responding on the key correlated with imipramine injections.”

“Further, several compounds including imipramine and propranolol, without known anorectic properties were among the most potent agents to inhibit [3H](+)-amphetamine binding.”

“It was found that in normal … release of NA evoked by (+)-amphetamine (5 X 10(-6) M) … mM) was antagonized by imipramine methiodide and desipramine, inhibitors of the NA uptake, but was not dependent on the … the medium and was not antagonized by the potent local anaesthetic agent bethoxycaine.”