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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Dextroamphetamine
drug:
Idazoxan
Research Papers that Mention the Interaction
“Combination of idazoxan with d-amphetamine did not antagonise the amphetamine cue but produced substantial reductions in response rates, probably due to toxicity.”
Behavioural effects of the α2-adrenoceptor antagonists idazoxan and yohimbine in rats: comparisons with amphetamine“administration of idazoxan , an alpha 2-adrenoceptor antagonist, reversed the effects of desipramine and d-amphetamine on the effectiveness of locus coeruleus stimulation and decreased that of microiontophoretically applied NE.”
“The selective alpha 2 antagonist, idazoxan , dose-dependently potentiated the action of AMPH and, in the presence of a constant dose of idazoxan, the dose-response curve for AMPH was shifted to the left.”
“In contrast, pretreatment with idazoxan (20 mg/kg) only marginally altered d-amphetamine hyperactivity.”
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