Possible Interaction: Dextroamphetamine and Haloperidol

“ Haloperidol prevented dextroamphetamine-induced behavioral excitation, but did not significantly affect plasma norepinephrine or pressor responses, whereas propranolol inhibited norepinephrine and pressor responses without influencing excitation or other behavioral responses.”

“The prolactin rise following dextroamphetamine was potentiated by haloperidol.”

“OBJECTIVE The authors sought to determine if an acute dose of dextroamphetamine might have positive effects on affect and cognition in schizophrenic patients maintained on a regimen of haloperidol and, if so, what variables might predict such improvements.”

“ Haloperidol controlled the symptoms and also antagonized the effect of dextroamphetamine.”

“When rats were pretreated for 8 … days with 2.0 mg/kg haloperidol , injection of 2.5 … 5.0 mg/kg d-amphetamine 2 or 6 days later resulted in a larger increase in oral behaviors and a more prolonged period of focused stereotypy than in saline-pretreated controls.”

“This behavioral supersensitivity was reduced by a single administration of d-amphetamine given 2 days after the termination of haloperidol injections.”

“ Chronic haloperidol enhanced the locomotor stimulant action of d-amphetamine , and this effect was attenuated by lithium.”

“Experiment III showed that LI could also be disrupted with 1 mg/kg d-amphetamine coupled with dopamine receptor supersensitivity produced by prolonged pretreatment with haloperidol.”

“Apomorphine (0.12--2 mg/kg, SC) and d-amphetamine (1--8 mg/kg, IP) were each able, at certain doses, to potentiate the cataleptic state produced by the neuroleptic agent, haloperidol (1 mg/kg, IP).”

“Acute pretreatments with the anti-psychotic dopamine blockers haloperidol and pimozide block stereotypy induced by both phenylethylamine and d-amphetamine , whereas antipsychotics with fewer extrapyramidal effects, thioridazine and clozapine, preferentially block phenylethylamine-evoked behavior.”

“The pecking response induced by d-amphetamine was antagonized by chlorpromazine, haloperidol or bulbocapnine indicating that this pecking response was caused by dopaminergic receptor stimulation.”