Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 4 months ago

Possible Interaction: Dextroamphetamine and Guanethidine

Research Papers that Mention the Interaction

Dexamphetamine and certain other indirectly acting sympathomimetic amines prevent or reverse the sympathetic nerve blocking action of guanethidine in anaesthetised cats and dogs.
The Journal of pharmacy and pharmacology  •  1962  |  View Paper
Dexamphetamine antagonized the sympathetic nerve block by guanethidine in the isolated hypogastric nerve-vas deferens preparation of the guinea-pig.
Dexamphetamine antagonized the sympathetic nerve block by guanethidine in the isolated sympathetically innervated rabbit ileum; the evidence suggests that the antagonism was competitive.
Doses of dexamphetamine , larger than those required to antagonize the blocking action of guanethidine , abolished the responses of the nictitating membrane, ileum and vas deferens to nerve stimulation.
British journal of pharmacology and chemotherapy  •  1963  |  View Paper
In contrast, guanethidine (0.2 mug ml(-1)) produced a slow onset blockade which was completely reversed by (+)-amphetamine.
The Journal of pharmacy and pharmacology  •  1976  |  View Paper
It is suggested that the antagonism between dexamphetamine and guanethidine is due to a reduction in the uptake of guanethidine by the nerve endings rather than to interaction of the two drugs at the receptor site for the adrenergic neurone blocking action of guanethidine.
British journal of pharmacology  •  1969  |  View Paper