Possible Interaction: Dextroamphetamine and Fenfluramine

“ d-Fenfluramine and d-amphetamine in combination produced the greatest cortisolaemic effect, suggesting that they act by differing neurochemical pathways.”

“Both isomers of fenfluramine were found to differ significantly in their effects from d-amphetamine , and from placebo, causing prolactin levels to rise.”

“ Fenfluramine was found to be at least 8 times as potent as dexamphetamine.”

“4,220 g.) in … patients taking the fenfluramine is greater than that obtained in trials of comparable duration in similar patients having … et al., 1960), diethylpropion (Seaton et al., 1961), chlorphentermine (Seaton et al., 1964a), and dexamphetamine and phentermine (Seaton et al., 1964b), … loss varied from 2.6 lb. (”

“A 3-day treatment with fenfluramine , or lesions of the median raphe nucleus (but not the dorsal raphe nucleus) abolished the ability of d-amphetamine to reduce motor activity in the three test systems.”

“Low doses of D-amphetamine and fenfluramine produced greater stimulus generalization when administered in combination than when given alone.”

“Treatment with d-fenfluramine (0.5 and 1 mg/kg) reduced responding for the CR, and abolished the potentiating effect of d-amphetamine.”

“It was found in an earlier study that a 15-day IP subacute d-amphetamine treatment rendered an apparent "tolerance" to the food intake suppressant effects of fenfluramine.”

“In an earlier study, it was found that a 15-day ip postfeeding session d-amphetamine treatment rendered an apparent "tolerance" to the feed intake suppressant effects of fenfluramine.”

“Combinations of d-amphetamine and d-fenfluramine produced greater deficits than each drug separately, with fewer correct responses and an increase in reinforcers earned but not consumed.”