Possible Interaction: Dextroamphetamine and Fenclonine

“The 5-hydroxytryptamine (5-HT) depleting agent p-chlorophenylalanine potentiated the effect of low doses of dexamphetamine but had no net effect on ED50 values; reserpine behaved similarly.”

“ Abstract P-chlorophenylalanine , an inhibitor of serotonin synthesis, was found to completely prevent the inhibitory effect of morphine and methadone on the stereotypy caused by d-amphetamine and methyl-phenidate in rats.”

“In contrast, pretreatment of WKY rats with parachlorophenylalanine resulted in an increase in rearing and a decrease in head waving following an injection of d-amphetamine.”

“The predominant effects produced by the low dose of D-amphetamine (0.5 mg/kg), i.e., enhanced crossovers and rearings, were found to be significantly elevated after PCPA administration.”

“However, in the frontal cortex, pCPA pretreatment augmented the amplitude of, and prolonged, the noradrenergic response to local infusion of d-amphetamine (10 microM).”

“In the hypothalamus, pCPA did not affect the amplitude of the response to either of these agents but did prolong the effects of d-amphetamine on noradrenaline efflux.”

“Both 5-hydroxytryptamine (5-HT) ICV and p-chlorophenylalanine potentiated the effect of d-amphetamine.”

“In contrast, the pronounced increase in firing rate produced by 7.5 mg/kg D-amphetamine in control rats was significantly reduced following PCPA pretreatment.”

“The differential effects of PCPA on the action of low and high doses of D-amphetamine in the anterior neostriatum may explain the differential influence of serotonergic systems on amphetamine-induced locomotion add stereotypy.”

“ PCPA pretreatment potentiated the increased accumulation of striatal [3H]dopamine (DA) induced by doses of AMPH to 1.5 mg/kg, and inhibited the decrease in striatal [3H]DA accumulation observed at higher doses (greater than 2.5 mg/kg) of AMPH.”

“Locomotor activity induced by d-amphetamine was found to be potentiated by food deprivation, a tryptophan-free diet, p-chlorophenylalanine and drugs proposed to antagonize serotonin receptors in brain.”

“Previous studies have reported that rats given either midbrain raphe lesions or the serotonin synthesis inhibitor, p-chlorophenylalanine , show an increase above controls in their locomotor response to various doses of (+)-amphetamine.”