Possible Interaction: Dextroamphetamine and Dopamine

“Furthermore, despite the standard practice of counterbalancing drug session order (AMPH first vs. placebo first), it remains understudied how AMPH may interact with practice effects, possibly influencing whether DA up-regulation is functional.”

“These results raise questions about the role of dopamine in d-amphetamine effects and suggest postneuroleptic dopamine receptor subsensitivity.”

“Abstract One of the major biochemical effects of d-amphetamine is the release and uptake inhibition of dopamine (DA).”

“An acute dose of (+)-amphetamine (15 mg/kg) decreased endogenous levels of DA and NE; normal levels of DA were detected with chronic drug treatment and during withdrawal, with NE remaining slightly depressed.”

“A variety of drugs which predominantly potentiate dopamine , including D-amphetamine , methamphetamine, MDMA, cocaine, and cathinone, all induce degeneration in axons from lateral habenula, through the sheath of FR, to midbrain cells such as SN, VTA, and raphe.”

“These results imply that brief periods of continuous d-Amp administration produce large and phasic changes in dopamine systems.”

“These owflations indicate that (+)-amphetamine is more potent in releasing dopamine than in inhibiting the dopamine uptake whereas methylphenidate is most potent as an inhibitor of the dopamine uptake.”

“Rats treated with 5 mg/kg d-amphetamine show a significant enhancement of the dopamine (DA) concentration (26%) in the brain stem 2 h p.i.”

“This is further supported by an inverse relationship between the in vitro dopamine uptake inhibitory concentrations and the sterotypy-inducing dose levels of nomifensine and d-amphetamine.”

“Thus there is a correlation between brain dopamine level and d-amphetamine-induced pecking response.”