Possible Interaction: Dextroamphetamine and Diazepam

“Daily treatment with the combination of 10 mg/kg diazepam and 1 mg/kg d-amphetamine caused a gradual increase in punished responding over 25 days under either shock intensity.”

“The combination of acute diazepam and d-amphetamine caused a decrease in shock rates as compared to diazepam alone.”

“An arousal hypothesis of hyponeophagia was proposed and supported by the antagonism of the sedative effects of 10.0 mg/kg diazepam by d-amphetamine (0.5 mg/kg).”

“ Diazepam reduced d-amphetamine response , but failed to influence PCP-induced stimulation.”

“The combination of 1.0 mg/kg d-amphetamine with the dose-range of diazepam generally potentiated the rate increasing effects of the drugs given singly.”

“ d-Amphetamine in combination with pentobarbital or diazepam also increased the duration of rotarod impairment.”

“Of the four depressants tested (1) only amobarbital enhanced the anorexic effects of d-amphetamine and (2) amobarbital, diazepam and prochlorperazine enhanced the hypermotility induced by d-amphetamine.”

“Inasmuch as DZP at low doses potentiates the effects of 4 different substances, the results can hardly be satisfactorily explained neither by an interference of the benzodiazepine on the metabolism of the drugs or by a depression of the anxiogenic action of dexamphetamine.”

“Abstract Pentobarbital, chlordiazepoxide, diazepam , meprobamate and piperacetazine antagonized the anorectic effect of d-amphetamine.”

“Pentobarbital significantly increased but diazepam and piperacetazine significantly decreased the motor stimulant effect of d-amphetamine.”